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Chemical constituents from Achyranthis Bidentata and their effects on cells proliferation / 中成药
Chinese Traditional Patent Medicine ; (12): 1320-1325, 2018.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-710303
Responsible library: WPRO
ABSTRACT
AIM To study chemical constitutes from Achyranthis bidentata Bl.and their effects on cells proliferation.METHODS The aqueous extract from dregs of a decoction of A.bidentata was isolated and purified by Diaion HP-20,Sephadex LH-20,ODS,silica and HPLC colum,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The effects on proliferation of endothelial cells were evaluated by MTT.RESULTS Ten compounds were isolated and identified as cynarasaponin A (1),ginsenoside R0 (2),chikusetsusaponin Ⅳ a (3),chikusetsusaponin Ⅳ a methyl ester (4),chikusetsusaponin Ⅳ a ethylester (5),chikusetsusaponin Ⅳ a butyl ester (6),chikusetsusaponin-1 (7),zingibroside R1 (8),3-O-β-D-glucuronic acid glycosides-oleanolic acid (9),3-O-β-D-glucuronic acid glycosides ethylester-oleanolic acid (10).Compounds 1,6,7,8 exhibited obviously inhibiting effects on HUVEC proliferation.CONCLUSION Compounds 1 and 10 are isolated from A.bidentata for the first time;compounds 1,6,7,8 have strong inhibiting effects on cells proliferation.

Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional Patent Medicine Year: 2018 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional Patent Medicine Year: 2018 Document type: Article
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