Relationship between multifunctional protein "clusterin" and Alzheimer's disease / 中华神经科杂志
Chinese Journal of Neurology
; (12): 768-773, 2018.
Article
in Zh
| WPRIM
| ID: wpr-711022
Responsible library:
WPRO
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that starts slowly and progressively leads to cognitive impairment.Clusterin,as an apolipoprotein,is usually widely expressed in mammalian brain tissue.In previous studies,below theories have been demonstrated:clusterin influences the aggregation,clearance and neurotoxicity of β-amyloid;compared to healthy people,AD patients show higher clusterin level in plasma and cerebrospinal fluid;the polymorphisms of clusterin gene encoding clusterin can enhance the incidence risk of AD.In addition,regulating the expression of clusterin in AD animals model has certain therapeutic effect on AD.Further investigating intrinsic relationship between clusterin and AD will help clarify the pathogenesis and establish a new therapeutic target of AD thus contributing to the prevention of Alzheimer's disease.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Neurology
Year:
2018
Document type:
Article