Current progress on the study of microparticles in ocular fundus diseases / 中华眼底病杂志

ABSTRACT

Microparticles are small vesicles that are released by budding of the plasma membrane during cellular activation and apoptotic cell breakdown.A spectrum of cell types can release microparticles including endothelial cells,platelets,macrophages,lymphocytes and tumor cells.Biological effects of microparticles mainly include procoagulant activity,inhibition of inflammation and cancer progression.The present study shows that vitreous microparticles isolated from proliferative diabetic retinopathy (PDR) stimulated endothelial cell proliferation and increased new vessel formation,promoting the pathological neovascularization in PDR patients.Oxidative stress induces the formation of retina pigment epithelium-derived microparticles carrying membrane complement regulatory proteins,which is associated with drusen formation and age related macular degeneration.Microparticles from lymphocyte (LMP) play an important role in anti-angiogenesis by altering the gene expression pattern of angiogenesis-related factors in macrophages.Besides,LMP are important proapoptotic regulators for retinoblastoma cells through reduction of spleen tyrosine kinase expression and upregulation of the p53-p21 pathway which ultimately activates caspase-3.However,how to apply the microparticles in the prevention and treatment of retinal diseases is a major challenge,because the study of the microparticles in the fundus diseases is still limited.Further studies conducted would certainly enhance the application of microparticles in the fundus diseases.