Perioperative implication of the endothelial glycocalyx / 대한마취과학회지
Korean Journal of Anesthesiology
; : 92-102, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-714306
Responsible library:
WPRO
ABSTRACT
The endothelial glycocalyx (EG) is a gel-like layer lining the luminal surface of healthy vascular endothelium. Recently, the EG has gained extensive interest as a crucial regulator of endothelial funtction, including vascular permeability, mechanotransduction, and the interaction between endothelial and circulating blood cells. The EG is degraded by various enzymes and reactive oxygen species upon pro-inflammatory stimulus. Ischemia-reperfusion injury, oxidative stress, hypervolemia, and systemic inflammatory response are responsible for perioperative EG degradation. Perioperative damage of the EG has also been demonstrated, especially in cardiac surgery. However, the protection of the EG and its association with perioperative morbidity needs to be elucidated in future studies. In this review, the present knowledge about EG and its perioperative implication is discussed from an anesthesiologist's perspective.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Phenobarbital
/
Thoracic Surgery
/
Blood Cells
/
Capillary Permeability
/
Endothelium, Vascular
/
Reperfusion Injury
/
Reactive Oxygen Species
/
Oxidative Stress
/
Glycocalyx
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2018
Document type:
Article