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Acute treatment of hyperammonemia by continuous renal replacement therapy in a newborn patient with ornithine transcarbamylase deficiency / 소아과
Article in English | WPRIM (Western Pacific) | ID: wpr-71581
Responsible library: WPRO
ABSTRACT
Ornithine transcarbamylase (OTC) deficiency is well known as the most common inherited disorder of the urea cycle, and 1 of the most common causes of hyperammonemia in newborns. We experienced a case of a 3-day-old boy with OTC deficiency who appeared healthy in the first 2 days of life but developed lethargy and seizure soon afterwards. His serum ammonia level was measured as >1700 microg/dL (range, 0 to 45 microg/dL). Continuous renal replacement therapy (CRRT) in the mode of continuous venovenous hemodiafiltration was immediately applied to correct the raised ammonia level. No seizure occurred after the elevated ammonia level was reduced. Therefore, CRRT should be included as 1 of the treatment modalities for newborns with inborn errors of metabolism, especially hyperammonemia. Here, we report 1 case of successful treatment of hyperammonemia by CRRT in a neonate with OTC deficiency.
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: Ornithine / Ornithine Carbamoyltransferase / Seizures / Urea / Renal Replacement Therapy / Hemodiafiltration / Ornithine Carbamoyltransferase Deficiency Disease / Hyperammonemia / Lethargy / Ammonia Limits: Humans / Infant / Infant, Newborn Language: English Journal: Korean Journal of Pediatrics Year: 2011 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Ornithine / Ornithine Carbamoyltransferase / Seizures / Urea / Renal Replacement Therapy / Hemodiafiltration / Ornithine Carbamoyltransferase Deficiency Disease / Hyperammonemia / Lethargy / Ammonia Limits: Humans / Infant / Infant, Newborn Language: English Journal: Korean Journal of Pediatrics Year: 2011 Document type: Article
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