Are We Predicting Disease Progress of the Rectal Cancer Patients without Surgery after Neoadjuvant Chemoradiotherapy? / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 634-645, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-715841
Responsible library:
WPRO
ABSTRACT
PURPOSE:
There are patients who do not undergo surgery, regardless of tumor response for neoadjuvant chemoradiotherapy (nCRT) in rectal cancer. However, there have been few reports focused on how oncologic outcomes are worse in these patients. We sought to investigate oncologic outcomes for these non-operated patients with rectal cancer after nCRT. MATERIALS ANDMETHODS:
A total of 1,063 records of patients with rectal cancer who were treated with nCRT from January 2002 to December 2013 were retrospectively reviewed. We categorized patients into the non-operated group (n=77), transanal local excision (TLE) group (n=54), ortotal mesorectal excision (TME) group (n=932) and compared each group using propensity score matching.RESULTS:
In the non-operated group, the most common reason for no surgery was patient refusal (n=64). Eleven patients were considered to have achieve clinical complete response (cCR), which was an independent prognostic factor of progression-free survival (p=0.045). In patients with disease progression in the non-operated group, the overall survival did not improved according to salvage treatments (p=0.451). The non-operated group showed worse survivals compared to the TLE or TME group before and after matching (p < 0.001). This finding was also noted in the analysis of survival only in patients with cCR.CONCLUSION:
In this study, non-operated patients did not secure oncologic safety regardless of cCR after nCRT. Our results suggest that a non-operative management must be carefully considered even if cCR is achieved.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Rectal Neoplasms
/
Retrospective Studies
/
Salvage Therapy
/
Disease-Free Survival
/
Disease Progression
/
Neoadjuvant Therapy
/
Propensity Score
/
Chemoradiotherapy
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2018
Document type:
Article