Survival Nomograms after Curative Neoadjuvant Chemotherapy and Radical Surgery for Stage IB2-IIIB Cervical Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 768-776, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-715980
Responsible library:
WPRO
ABSTRACT
PURPOSE:
The purpose of this study was to develop nomograms for predicting the probability of overall survival (OS) and progression-free survival (PFS) in locally advanced cervical cancer treated with neoadjuvant chemotherapy and radical surgery. MATERIALS ANDMETHODS:
Nomograms to predict the 5-year OS rates and the 2-year PFS rates were constructed. Calibration plots were constructed, and concordance indices were calculated. Evaluated variableswere body mass index, age, tumor size, tumor histology, grading, lymphovascular space invasion, positive parametria, and positive lymph nodes.RESULTS:
In total 245 patients with locally advanced cervical cancer who underwent neoadjuvant chemotherapy and radical surgery were included for the construction of the nomogram. The 5-year OS and PFS were 72.6% and 66%, respectively. Tumor size, grading, and parametria status affected the rate of OS, whereas tumor size and positive parametria were the main independent PFS prognostic factors.CONCLUSION:
We constructed a nomogram based on clinicopathological features in order to predict 2-year PFS and 5-year OS in locally advanced cervical cancer primarily treated with neoadjuvant chemotherapy followed by radical surgery. This tool might be particularly helpful for assisting in the follow-up of cervical cancer patients who have not undergone concurrent chemoradiotherapy.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Calibration
/
Body Mass Index
/
Uterine Cervical Neoplasms
/
Follow-Up Studies
/
Disease-Free Survival
/
Nomograms
/
Drug Therapy
/
Chemoradiotherapy
/
Lymph Nodes
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2018
Document type:
Article