Applications of kidney organoids derived from human pluripotent stem cells
The Korean Journal of Internal Medicine
; : 649-659, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-716083
Responsible library:
WPRO
ABSTRACT
The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing of compounds, and regenerative therapy are attractive applications. Although much progress still remains to be made in the development of kidney organoids, recent advances in clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated system 9 (Cas9) genome editing and three-dimensional bioprinting technologies have contributed to the application of kidney organoids in clinical fields. In this section, we review recent advances in the applications of kidney organoids to kidney disease modelling, drug screening, nephrotoxicity testing, and regenerative therapy.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Transplantation
/
Organoids
/
Genome
/
Pluripotent Stem Cells
/
Regenerative Medicine
/
Drug Evaluation, Preclinical
/
Bioprinting
/
Clustered Regularly Interspaced Short Palindromic Repeats
/
Kidney
/
Kidney Diseases
Type of study:
Practice guideline
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2018
Document type:
Article