A triage strategy in advanced ovarian cancer management based on multiple predictive models for R0 resection: a prospective cohort study / 부인종양
Journal of Gynecologic Oncology
; : e65-2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-717072
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To present the surgical outcomes of advanced epithelial ovarian cancer (AEOC) since the implementation of a personalized approach and to validate multiple predictive models for R0 resection.METHODS:
Personalized strategies included 1) Non-invasive model preoperative clinico-radiological assessment according to Suidan criteria with a predictive score for all individuals. Patients with a score 0–2 were recommended for primary debulking surgery (PDS, group A), or otherwise were counseled on the choices of PDS, neoadjuvant chemotherapy (NAC, group B) or staging laparoscopy (S-LPS). 2) Minimally invasive model S-LPS with a predictive index value (PIV) according to Fagotti. Individuals with a PIV < 8 underwent PDS (group C) or otherwise received NAC (group D). Intraoperative assessment (with Eisenkop, peritoneal cancer index [PCI], and Aletti scores) and surgical results were prospectively collected.RESULTS:
Between September 2015 and August 2017, 161 pathologically confirmed epithelial ovarian cancer patients were included. A total of 52 (32.3%) patients had a predictive score of 0–2, and 109 (67.7%) patients had a score ≥ 3. Among these individuals, 41 (25.5%) patients received S-LPS. Finally, 110 (68.3%) patients underwent PDS (A+C), and 51 (31.7%) patients received NAC (B+D). The R0 resection rates in PDS and NAC patients were 56.4% and 60.8%, respectively. The area under the curve (AUC) of Suidan criteria was 0.548 for group (A+C). The AUC of Fagotti score was 0.702 for group C. The AUC of Eisenkop, PCI, and Aletti scores were 0.808, 0.797, and 0.524, respectively.CONCLUSION:
The Suidan criteria were not effective in these AEOC patients. S-LPS was helpful in decision-making for PDS and should be endorsed in the future.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Research Design
/
Prospective Studies
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Cohort Studies
/
Triage
/
Laparoscopy
/
Area Under Curve
/
Drug Therapy
Type of study:
Etiology study
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Incidence study
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Observational study
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Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Gynecologic Oncology
Year:
2018
Document type:
Article