Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence
Korean Journal of Ophthalmology
; : 353-360, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-717336
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To describe the clinical manifestations of herpes simplex keratitis (HSK) in a tertiary referral center in South Korea and to determine whether ascorbic acid treatment prevents recurrence of herpetic epithelial keratitis.METHODS:
This retrospective cohort study included all consecutive patients with herpetic keratitis referred to our center from January 2010 to January 2015. Clinical features, ocular complications, and recurrences were recorded.RESULTS:
In total, 149 eyes of the 133 patients (72 male and 61 female) were followed for an average of 24.6 ± 13.2 months. Sixteen (12.0%) patients had bilateral HSK. The most frequent HSK subtype was epithelial keratitis (49.7%), which was followed by stromal keratitis (23.5%). Epithelial keratitis was the most likely subtype to recur. Complications occurred in 122 (81.9%) eyes. The most common complication was corneal opacity. Recurrences were observed in 48 (32.2%) eyes. The recurrence rates were lower in the prophylactic oral antiviral agent group (16 / 48 eyes, 33.3% vs. 49 / 101 eyes, 48.5%) and the ascorbic acid treatment group (13 / 48 eyes, 27.1% vs. 81 / 101 eyes, 70.3%) compared with the groups without medications. Univariate logistic regression analysis revealed that both factors significantly reduced the risk of recurrence (acyclovir odds ratio, 0.25; 95% confidence intervals, 0.12 to 0.51; ascorbic acid odds ratio, 0.51; 95% confidence intervals, 0.20 to 0.91).CONCLUSIONS:
This retrospective study described the clinical findings of HSK in a tertiary referral center in South Korea. Prophylactic oral antiviral agent treatment and oral ascorbic acid administration may lower the risk of recurrence.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Ascorbic Acid
/
Recurrence
/
Acyclovir
/
Logistic Models
/
Odds Ratio
/
Retrospective Studies
/
Cohort Studies
/
Keratitis, Herpetic
/
Corneal Opacity
/
Tertiary Care Centers
Type of study:
Etiology study
/
Incidence study
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Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2018
Document type:
Article