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Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
Article in English | WPRIM (Western Pacific) | ID: wpr-718355
Responsible library: WPRO
ABSTRACT

OBJECTIVE:

This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL).

METHODS:

We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPV cohort study. The cohort recruited women aged 20–60 years with abnormal cervical cytology (ASC-US or LSIL) from April 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing.

RESULTS:

Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At the time of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytology performed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% of the women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than that with infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08–2.84; P=0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women with incidental or cleared infections (P < 0.001). Logistic regression analysis showed a significant relationship between cigarette smoking and cytological progression (RR, 4.15; 95% CI, 1.01–17.00).

CONCLUSION:

The cytological progression rate in HPV 16-positive women with ASC-US or LSIL is higher than that in women infected with other HPV types. Additionally, cigarette smoking may play a role in cytological progression.
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: Papillomaviridae / Smoking / Logistic Models / Epidemiology / Risk Factors / Cohort Studies / Follow-Up Studies / Human papillomavirus 16 / Human Papillomavirus DNA Tests / Atypical Squamous Cells of the Cervix Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Female / Humans Language: English Journal: Obstetrics & Gynecology Science Year: 2018 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Papillomaviridae / Smoking / Logistic Models / Epidemiology / Risk Factors / Cohort Studies / Follow-Up Studies / Human papillomavirus 16 / Human Papillomavirus DNA Tests / Atypical Squamous Cells of the Cervix Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Female / Humans Language: English Journal: Obstetrics & Gynecology Science Year: 2018 Document type: Article
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