Amelioration of experimental autoimmune encephalomyelitis by Ishige okamurae / 대한해부학회지
Anatomy & Cell Biology
; : 292-298, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-718950
Responsible library:
WPRO
ABSTRACT
Experimental autoimmune encephalomyelitis (EAE) is a T-cell-mediated autoimmune central nervous system disease characterized by inflammation with oxidative stress. The aim of this study was to evaluate an anti-inflammatory effect of Ishige okamurae on EAE-induced paralysis in rats. An ethanolic extract of I. okamurae significantly delayed the first onset and reduced the duration and severity of hind-limb paralysis. The neuropathological and immunohistochemical findings in the spinal cord were in agreement with these clinical results. T-cell proliferation assay revealed that the ethyl-acetate fraction of I. okamurae suppressed the proliferation of myelin basic protein reactive T cells from EAE affected rats. Flow cytometric analysis showed TCRαβ+ T cells was significantly reduced in the spleen of EAE rats with I. okamurae treatment with concurrent decrease of inflammatory mediators including tumor necrosis factor-α and cyclooxygenase-2. Collectively, it is postulated that I. okamurae ameliorates EAE paralysis with suppression of T-cell proliferation as well as decrease of pro-inflammatory mediators as far as rat EAE is concerned.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Paralysis
/
Spinal Cord
/
Spleen
/
T-Lymphocytes
/
Central Nervous System
/
Oxidative Stress
/
Ethanol
/
Myelin Basic Protein
/
Encephalomyelitis, Autoimmune, Experimental
/
Cyclooxygenase 2
Limits:
Animals
Language:
English
Journal:
Anatomy & Cell Biology
Year:
2018
Document type:
Article