A case of transfusion-related acute lung injury induced by anti-human leukocyte antigen antibodies in acute leukemia
Korean Journal of Hematology
; : 302-306, 2012.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-720305
Responsible library:
WPRO
ABSTRACT
Transfusion-related acute lung injury (TRALI) is a noncardiogenic pulmonary edema that occurs during or within 6 hours after transfusion. Risk factors for TRALI, which is relatively common in critically ill patients, include recent surgery, hematologic malignancy, and sepsis. Here, we report a case of TRALI induced by anti-human leukocyte antigen (anti-HLA) class II antibodies (HLA-DR) occurring after transfusion of platelet concentrates in a patient with acute leukemia. Although most patients with TRALI show improvement within 48-96 hours, our patient's condition rapidly worsened, and he did not respond to supportive treatment. TRALI is a relatively common and serious adverse transfusion reaction that requires prompt diagnosis and management.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pulmonary Edema
/
Blood Group Incompatibility
/
Blood Platelets
/
Leukemia
/
Risk Factors
/
Critical Illness
/
Sepsis
/
Hematologic Neoplasms
/
Acute Lung Injury
/
Leukocytes
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Korean Journal of Hematology
Year:
2012
Document type:
Article