A Case of Acute Promyelocytic Leukemia with 46, XX, del(5)(q23)/47, XX, del(5)(q23), +8 but Without (15;17) Translocation / 대한혈액학회지
Korean Journal of Hematology
; : 174-178, 2000.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-720779
Responsible library:
WPRO
ABSTRACT
Acute promyelocytic leukemia (APL/AML- M3) is a distinct subtype of acute myelogenous leukemia, which is characterized by unique morphologic, cytogenetic, molecular, and clinical features. In almost all APL patients, a characteristic t(15;17)(q22;q21) is found, resulting from the fusion of the PML gene and retinoic acid receptor alpha (RAR ) gene. This chromosomal translocation in APL may present variant translocations, and may be associated with secondary chromosomal abnormalities. The most frequent accompanying karyotypic aberration is trisomy 8 in APL. We are reporting a case of a 17-year-old woman who was diagnosed with APL. Cytogenetic study revealed that 46, XX, del(5)(q23)/47, XX, del(5)(q23), +8 chromosomal abnormality but without t(15;17). However, the presence of PML/RAR chimera was found with reverse transcriptase PCR. It is well known that the association of trisomy 8 on top of t(15;17) in APL cases. However, in our review, the mosaicism of del(5)(q23) with trisomy 8 in APL might be the first case. Whether this patient will behave the typical APL cases having good prognosis or not will be interesting to see.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Translocation, Genetic
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Trisomy
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Leukemia, Myeloid, Acute
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Leukemia, Promyelocytic, Acute
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Chimera
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Chromosome Aberrations
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Receptors, Retinoic Acid
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Reverse Transcriptase Polymerase Chain Reaction
/
Cytogenetics
Type of study:
Prognostic study
Limits:
Adolescent
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Hematology
Year:
2000
Document type:
Article