Prognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal Atrophy
Journal of Clinical Neurology
; : 234-242, 2017.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-72147
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
Only a few studies have investigated the relationship between different subtypes and disease progression or prognosis in patients with behavioral variant frontotemporal dementia (bvFTD). Since a localized injury often produces more focal signs than a diffuse injury, we hypothesized that the clinical characteristics differ between patients with bvFTD who show diffuse frontal lobe atrophy (D-type) on axial magnetic resonance imaging (MRI) scans versus those with focal or circumscribed frontal lobe atrophy (F-type).METHODS:
In total, 94 MRI scans (74 scans from bvFTD and 20 scans from age-matched normal controls) were classified into 35 D- and 39 F-type bvFTD cases based on an axial MRI visual rating scale. We compared baseline clinical characteristics, progression in motor and cognitive symptoms, and survival times between D- and F-types. Survival analyses were performed for 62 of the 74 patients.RESULTS:
While D-type performed better on neuropsychological tests than F-type at baseline, D-type had higher baseline scores on the Unified Parkinson's Disease Rating Scale (UPDRS) Part III. Evaluations of motor progression showed that the disease duration with motor symptoms was shorter in D-type than F-type. Moreover, the survival time was shorter in D-type (6.9 years) than F-type (9.4 years). Cox regression analyses revealed that a high UPDRS Part III score at baseline contributed to an increased risk of mortality, regardless of the pattern of atrophy.CONCLUSIONS:
The prognosis is worse for D-type than for those with F-type. Shorter survival in D-type may be associated with the earlier appearance of motor symptoms.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Alzheimer’s Disease and other Dementias
/
Endocrine System Diseases
/
Mental Health and Behavioral Disorders
/
Parkinson Disease
Database:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Prognosis
/
Atrophy
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Magnetic Resonance Imaging
/
Mortality
/
Disease Progression
/
Neurobehavioral Manifestations
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Frontotemporal Lobar Degeneration
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Frontotemporal Dementia
/
Frontal Lobe
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2017
Document type:
Article