Comparing Biological Markers of Alcohol Dependence in the Patients of an Alcohol Counseling Center
Journal of the Korean Society of Biological Psychiatry
; : 273-278, 2006.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-725213
Responsible library:
WPRO
ABSTRACT
OBJECTIVES:
Biochemical markers can provide an objective evidence of heavy alcohol drinking. The purpose of this study was to compare and evaluate the usefulness of biological markers detecting alcohol dependence, such as mean corpuscular volume(MCV), gamma-glutamyl transferase(GGT), and carbohydrate-deficient transferrin(CDT) in the patients of an alcohol counseling center.METHODS:
This study was done with 64 patients with alcohol dependence and 36 healthy subjects. Relative values(%) of CDT were determined in their sera with turbidimetric immunoassay(Bio-Rad %CDT assay, Axis-Shield ASA, Oslo, Norway), and were compared with conventional markers of alcohol consumption, GGT and MCV.RESULTS:
Among the patients with alcohol dependence, 78.1% showed abnormal %CDT levels compared with GGT(61.9%) and MCV(20.7%). The areas under the receiver operating characteristic(ROC) curves(95% confidence interval) for %CDT, GGT, and MCV were 0.934(0.866-0.973), 0.871(0.789-0.930), and 0.575 (0.472-0.673), respectively.CONCLUSION:
%CDT seems to be the most reliable biological marker for the detection and monitoring of alcohol consumption in the patients with alcohol dependence of the alcohol counseling center.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 -Target 3.5 Prevention and treatment of consumption of psychoactive substances
Health problem:
Target 3.5: Prevention and treatment of consumption of psychoactive substances
/
Alcohol
Database:
WPRIM (Western Pacific)
Main subject:
Alcohol Drinking
/
Biomarkers
/
Counseling
/
Alcoholism
/
Erythrocyte Indices
/
Gamma-Glutamyltransferase
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Biological Psychiatry
Year:
2006
Document type:
Article