A Case of Autoantibody-Positive Ketosis-Prone Diabetes Mellitus / 임상당뇨병
Journal of Korean Diabetes
; : 60-66, 2016.
Article
in Ko
| WPRIM
| ID: wpr-726754
Responsible library:
WPRO
ABSTRACT
Ketosis-prone diabetes mellitus (KPD), which is an atypical type of diabetic mellitus with severe β cell dysfunction, is accompanied by ketosis or ketoacidosis without specific preceding factors at diagnosis. KPD shows mixed features of type 1 and type 2 diabetes. In some cases, the recovery of the function of β cells during intensified diabetic management enabled the termination of insulin therapy. The Aβ classification system classifies KPD patients into four distinct subgroups depending upon the presence or absence of β cell autoimmunity and β cell functional reserve and has been recognized as an important tool to predict clinical outcomes. In Korea, several cases of KPD with absence of β cell autoimmunity have been reported. A 60-year-old man presenting with DKA (diabetic ketoacidosis) as the first manifestation of diabetes, was shown to have β cell autoimmunity. A significant improvement in glycemic control was shown as a result of aggressive diabetic management; shortly after an acute episode of DKA, the recovery of β cell functional reserve was confirmed. This result allowed discontinuation of insulin therapy and maintenance of euglycemic status without antidiabetic medication.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Autoimmunity
/
Classification
/
Diabetic Ketoacidosis
/
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
/
Diagnosis
/
Insulin
/
Ketosis
/
Korea
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
Ko
Journal:
Journal of Korean Diabetes
Year:
2016
Document type:
Article