Increased Rate of Palmitate Oxidation in Adults Female: Comparison with Peri-pubertal Young Female Rats
The Korean Journal of Physiology and Pharmacology
; : 283-287, 2006.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-727443
Responsible library:
WPRO
ABSTRACT
Although estrogen is known to play a role in fatty acid metabolism, it remains unclear whether fatty acid oxidation in mature female rats differs from fatty acid oxidation in peri-pubertal young rats. In this study, we measured fatty acid metabolism in the skeletal muscles and livers of 5 and 50 weeks old male and female rats. The rate of palmitate oxidation in the liver and gastrocnemius red in the 50-week-old female rats were elevated as compared to the 5-week-old females, whereas there were no differences in the male rats. The rate of palmitate oxidation in the gastrocnemius red was correlated inversely with intra-abdominal fat mass in the 5-week-old male and female rats, whereas the palmitate oxidation rate was positively correlated with fat mass in the liver and gastrocnemius red in the 50-week-old rats. HOMA-IR and plasma insulin levels were positively correlated with intra-abdominal fat mass in the pooled 50-week-old male and female rats, but this correlation was not apparent in 5-week-old rats. In summary, the rate of fatty acid oxidation measured in the middle-aged adult female rats was significantly higher than those measured in the peri-pubertal young female rats. This difference may be attributed to the influence of ovarian hormones.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Muscle, Skeletal
/
Intra-Abdominal Fat
/
Estrogens
/
Insulin
/
Liver
/
Metabolism
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2006
Document type:
Article