Pharmacokinetics of Dehydroevodiamine Following Intravenous Administration in Rats
The Korean Journal of Physiology and Pharmacology
; : 65-67, 2004.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-728501
Responsible library:
WPRO
ABSTRACT
Dehydroevodiamine (DHED) is one of the bioactive components of the Chinese herbal medicine Wu-chu-yu-tang that has been shown to produce various pharmacological effects. In the present study, we investigated the pharmacokinetics of DHED after intravenous administration of two doses (2.5 and 5 mg/kg) in anesthetized rats. The plasma concentration of DHED was measured by reverse-phase high-performance liquid chromatography with UV detection. The mean area under the curve of the time-concentration profile was 21.9 and 53.9 microgram-min/ml after the 2.5- and 5-mg/kg doses, respectively, and the volume of distribution was 1584.9 and 1580.6 ml following 2.5- and 5-mg/kg doses, respectively. Plasma concentration profiles versus time were compatible with a two-compartment model and first-order kinetics. The terminal elimination half-life was 91.8+/-16.6 min and 78.7+/-11.9 min in the dose of 2.5 and 5 mg/kg, respectively. This is the first report to study the pharmacokinetics of DHED in animals.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Pharmacokinetics
/
Kinetics
/
Chromatography, High Pressure Liquid
/
Chromatography, Liquid
/
Herbal Medicine
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Asian People
/
Administration, Intravenous
/
Half-Life
/
Injections, Intravenous
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2004
Document type:
Article