Lipoxygenase Inhibitory Activity of Korean Indigenous Mushroom Extracts and Isolation of an Active Compound from Phellinus baumii
Mycobiology
; : 185-188, 2014.
Article
in En
| WPRIM
| ID: wpr-729226
Responsible library:
WPRO
ABSTRACT
We investigated a total of 335 samples of Korean native mushroom extracts as part of our lipoxygenase (LOX) inhibitor screening program. Among the mushroom-methanolic extracts we investigated, 35 exhibited an inhibitory activity greater than 30% against LOX at a concentration of 100 microg/mL. Especially, Collybia maculata, Tylopilus neofelleus, Strobilomyces confusus, Phellinus gilvus, P. linteus, P. baumii, and Inonotus mikadoi exhibited relatively potent LOX inhibitory activities of 73.3%, 51.6%, 52.4%, 66.7%, 59.5%, 100.0%, and 85.2%, respectively. Bioassay-guided fractionation led to the isolation of inoscavin A from the methanolic extract of P. baumii, which showed the most potent activity and was identified by spectroscopic methods. Specifically, inoscavin A exhibited potent LOX inhibitory activity with an IC50 value of 6.8 microM.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Mass Screening
/
Lipoxygenase
/
Inhibitory Concentration 50
/
Agaricales
/
Methanol
Type of study:
Screening_studies
Language:
En
Journal:
Mycobiology
Year:
2014
Document type:
Article