The role of mitochondria in the pathogenesis of bronchial asthma / 国际儿科学杂志

ABSTRACT

Bronchial asthma is a heterogeneous disease characterized by chronic airway inflammation,and its pathogenesis is complex.Epithelial mitochondrial damage is one of the important pathogenesis of asthma and an important bridge between airway inflammation and airway remodeling.Inhibition of mitochondrial damage,and thus inhibition of oxidative stress,may be an effective method to reduce epithelial cell damage and inhibit airway remodeling,which may be a breakthrough in asthma treatment.This review summarizes the role of mitoehondria in the pathogenesis of asthma.