Progress on phospholipid in pulmonary surfactant / 国际儿科学杂志

ABSTRACT

Pulmonary surfactant is a kind of phospholipid and protein complexes,synthesized from type Ⅱ alveolar epithelial cells.The primary function of PS is to minimize the surface tension at the alveolar air-liquid interface.The deficiency of phospholipid synthesis or function leads to the occurrence of many lung diseases,such as neonatal respiratory distress syndrome,which seriously affects the morbidity and morality of neonates.Phospholipids are the main form of PS,accounting for about 85％ ～ 90％,and the main active component is dipalmitoylphosphatidylcholine,which is the most important material basis for PS to exert biological activity.In recent years,studies on phospholipids have attracted wide attention,so this article reviews the progress on composition,structure,biological characteristics,physiological function,metabolic regulation and detection methods of phospholipids.