Relationship of obstructive sleep apnea hypopnea syndrome and erythropoietin in children / 中华实用儿科临床杂志

ABSTRACT

Objective To observe the effect of hypoxemia in children with obstructive sleep apnea hypopnea syndrome (OSAHS) on erythropoietin (EPO) and hypoxia-inducible factor 1α (HIF-1α) levels in serum,and to learn the changes in endocrine and its relationship to growth in OSAHS children.Methods Seventy children with snoring were selected from Jun.2006 to Jun.2010 from the First Hospital of Hebei Medical University.Apnea hypopnea index ≥5 times/hour observed by the polysomnography,and the minimum oxygen saturation ＜ 92％ were taken as the standard,then the children were divided into OSAHS group (38 cases) and PS group (32 cases).The red blood cell count,hemoglobin,hematocrit,mean corpuscular volume,red cell distribution width,serum erythropoietin and hypoxia-inducible factors were observed and analysed statistically between the 2 groups.Results 1.Between OSAHS group and PS group,the differences of red blood cell count,hemoglobin and hematocrit were statistically significant (all P ＜ 0.01).Mean corpuscular volume and red cell distribution width showed no significant difference between both groups (all P ＞0.05).2.The EPO level in OSAHS group was higher than that in the PS group,the difference was significanty (P ＜0.01).3.The serum levels of HIF-1α showed no significant difference between the 2 groups(P ＞ 0.05).Conclusions Hypoxemia induced by OSAHS can cause the changes in endocrine and the concentration of blood formed elements.This change is one of the most important process in physiological changes in children with OSAHS,and meanwhile it can also influence the growth of children.