Levofloxacin distribution in serum and ascites in patients with cirrhosis and evaluation of its efficacy in treatment of spontaneous bacterial peritonitis / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 354-356, 2001.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-735381
Responsible library:
WPRO
ABSTRACT
Objective:
To study the distribution of levofloxacin in the serum and ascites in patients with cirrhosis and to evaluate its efficacy in treatment of patients with spontaneous bacterial peritonitis(SBP).Methods:
(1)Concentration of levofloxacin in the serum and ascites was detected with HPLC in 7 patients with cirrhosis at different time (in the serum 0.5, 1, 1.5, 2 and 12 h;in the ascites2, 4, 6 and 12 h). (2)The effects of levofloxacin were observed in treatment of 30 patients with SBP.Results:
(1) Levofloxacin was determined in serum and ascites of patients with cirrhosis, whose concentration depended on the duration after oral administration. In serum tmax was 1.5 h and cmax was (3.913±1.388) μg/ml. In ascites tmax was 6.0 h and cmax was (2.520±1.213) μg/ml. The levels decreased gradually after reaching peak concentration, then stabilized from 12 h.(2)The symptoms and signs were significantly improved in patients with SBP treated with the levofloxacin.Conclusion:
After the oral administration, levofloxacin can both distribute in serum and ascites, and it is efficient in the treatment of the patients with SBP.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Document type:
Article