Optimal Supply of Precursors for CoQ10 Production by Rhodopseudomonas Palustris / 现代生物医学进展
Progress in Modern Biomedicine
; (24): 845-850, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-735607
Responsible library:
WPRO
ABSTRACT
CoQ10 has been used not only as a medicine but also as food supplements because of its various physiological and biochemical activities. A full-factorial central composite design and response surface methodology were used for optimizing three precursors Solanesol, 4-hydroxybenzoic acid and methionine to maximize the production of CoQ10 by Rhodopseudomonas palustris J001. The optimization of the model predicted a maximum response 40.6 [(mg CoQ10)(g dried biomass)-1] CoQ10 production with 124.8 mg l-1 Solanesol, 267.7 mg l-14-hydroxybenzoic acid and 130.2 mg l-1 methionine, respectively. A new combination was prepared according to the result. The observed response was 40.5 ± 0.2 [(mg CoQ10)(g dried biomass)-1] and was 109.8%higher than in the control with no addition of the three precursors.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Progress in Modern Biomedicine
Year:
2008
Document type:
Article