Effects of Intrarenal Arterial Infusion of Arginine Vasopressin on the Renal Function and Renin Release in Conscious Rabbits / 대한신장학회잡지

ABSTRACT

Arginine vasopressin(AVP) released from the posterior pituitary gland is well known to cause an increase in blood pressure, antidiuresis, natriuresis and inhibition of renin secretion. However, the mechanism involved in AVP-induced natriuresis is still unknown. To investigate the mechanism of AVP- induced natriuresis, different doses of AVP were infused into the left renal artery for 10 min and renal function and data were obtained in unanesthetized rabbits. Infusion of different doses of AVP (0.3pg/kg/min-10,000pg/kg/min) caused marked decreases in urine volume, renal blood flow, glomerular filtration rate and free water clearance without changes in blood pressure. Changes in renal function by AVP were not dose-dependent but it took more time for the renal function to recover with increasing doses. Infusion of large doses of AVP(3,000, 10,000pg/kg/min) caused increases in sodium excretion in both kidneys without changes in blood pressure. Infusion of AVP caused a decrease in renin secretion rate. In indomethacin-treated rabbits, changes in urine volume and renal hemodynamics by AVP were markedly accentuated whereas natriuretic effects were attenuated. However, a marked natriuresis caused by AVP in control right kidney still persistently existed. These results suggest that the AVP-induced natriuresis may occur in two-different ways one is indirect hormonal including prostaglandins and the other is tubular.