Clinical outcomes of synchronous head and neck and esophageal cancer
Radiation Oncology Journal
; : 172-178, 2015.
Article
in En
| WPRIM
| ID: wpr-73640
Responsible library:
WPRO
ABSTRACT
PURPOSE: To investigate clinical outcomes of synchronous head and neck and esophageal cancer (SHNEC). MATERIALS AND METHODS: We retrospectively reviewed 27 SHNEC patients treated with curative intent at a single institution. The treatment modality for individual cases was usually determined on a case by case basis. RESULTS: The median follow-up duration for the surviving patients was 28.2 months. The most common site of head and neck cancer was hypopharyngeal carcinoma (n = 21, 77.7%). The lower esophagus was the most common location of esophageal carcinoma (n = 16, 59.3%). The 2-year progression-free survival (PFS) and overall survival (OS) rates were 57.5% and 39.6%. Major pattern of failure was locoregional recurrence in the study patients. Esophageal cancer stage, the Eastern Cooperative Oncology Group (ECOG) performance status, and pretreatment weight loss were significant prognostic factors for OS in univariate analysis. Treatment-related death was observed in two patients, and one patient developed a grade 4 late treatment-related complication. CONCLUSION: Although the survival outcome for SHNEC is poor, long-term survival might be achievable with aggressive treatment with stage I-II esophageal cancer and good performance.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Recurrence
/
Esophageal Neoplasms
/
Weight Loss
/
Retrospective Studies
/
Follow-Up Studies
/
Disease-Free Survival
/
Esophagus
/
Head
/
Head and Neck Neoplasms
/
Neck
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Radiation Oncology Journal
Year:
2015
Document type:
Article