Human leukocyte antigen polymorphism of HIV infected persons without disease progress for long-term in Henan province, 2011-2016 / 中华流行病学杂志

ABSTRACT

Objective To understand the disease progression and human leukocyte antigen (HLA) gene polymorphism of HIV-infected persons without disease progress for long term,also known as long-term non-progressors (LTNPs),in Henan province.Methods A retrospective study was conducted in 48 LTNPs with complete detection and follow-up information during 2011-2016 in Henan.Changes of CD4 +T cells counts (CD4) and viral load (VL) during follow-up period were discussed.Polymerase chain reaction-sequence-specific oligonucleotide probe (PCR-SSOP) was used for the analyses of HLA-A,HLA-B and HLA-DRB1 alleles between LTNPs and healthy controls.Results From 2011 to 2016,forty-eight LTNPs showed a decrease of the quartile (P25-P75) of CD4 from 601.00 (488.50-708.72)/μl to 494.00 (367.00-672.00)/μl,and the difference was significant (P＜0.05).The increase of the quartile (P25-P75) of log10VL from 3.40 (2.87-3.97) to 3.48 (2.60-4.37),but the difference was not significant (P＞0.05).HLA polymorphism analysis revealed that HLA-B*1302 and HLA-B*4006 were more common in LTNPs (P＜0.05),while HLA-B*4601 and HLA-DRB1*0901 were more common in healthy controls (P＜0.05).Conclusions The CD4 of LTNPs in Henan showed a downward trend year by year.HLA-B*1302 and B*4006 might be associated with delayed disease progression for HIV infected persons in Henan.