Study on the pharmacolinetics,tissue distridution and excretion of nerve growsth factof in mice / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 65-67, 2001.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-736803
Responsible library:
WPRO
ABSTRACT
Objective:
To study the pharmacokinetics,thissue distribution and secretion of nerve growth factor(NGF)in mice.Methods:
The conecntration of NGF in various body fluids and tissue were determined by isotope tracer combined SDSPAGE method.Results:
The plasma concenmtration-time curve was in accordance with the two-compartment pharmacokinetic model.The elimation half-life(t1/2β)was 3.1.The half-life of distribution(t1/2ka)was 5min.Tpeak was 25 min.AUC was 72.4 mg·kg-1·h-1.The concentrations of NGF were high in thyroid,blood,submaxillary glands,superior cervical ganglion,adrenasl and kidneys.Conclusion:
NGF has a wide distribution,high tissue concentrationa nd excrtet mainly through the urine.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Academic Journal of Second Military Medical University
Year:
2001
Document type:
Article