Incidence of amiodarone-induced thyroid dysfunction in Korean / 대한내과학회지
Korean Journal of Medicine
; : 664-669, 2003.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-7412
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Amiodarone is an effective antiarrhythmic agent, but it is used restrictively due to several side effects. Amiodarone has been caused thyroid dysfunction, thyroid hyperfunction or hypofunction in several clinical studies. In this study, we assessed the clinical features, frequency and nature of thyroid dysfunction in patients with amiodarone therapyMETHODS:
A total of 150 patients (Male;n=71, Female;n=79) was assessed. They had never had the history of thyroid disease and had been received amiodarone therapy. All the patient's medical records on therapeutic dose and duration, body weight, height, body mass index and thyroid function test were reviewed. Patient's underlying diseases were supraventricular arrhythmia (n=54) and ventricular arrhythmia (n=96). The dose of amiodarone was between 100 mg and 400 mg, and the mean duration of therapy was 36 months. We defined decreased TSH with elevated T3 and T4 as thyrotoxicosis, and elevated TSH as hypothyroidismRESULTS:
Thyroid dysfunction was observed in 56 (37.3%) patients and their mean body mass index (BMI) was 23.6 kg/m2. Of them, thyrotoxicosis and hypothyroidism were observed in 5 (3.3%) patients and 51 (34%) patients, respectively. The difference of sex in hypothyroidism was almost not visible (male;n=24, female;n=27), also the correlation with BMI and thyroid function was not (mean BMI=23.7 kg/m2). Amiodarone was maintained for 46 months in hypothyroidism patients, that was more longer duration than normal thyroid patients (30 months).CONCLUSION:
In korean patients with amiodarone therapy, one third patients presented thyroid dysfunction and most of them were hypothyroidism. No correlation was found between thyroid dysfunction and sex and BMI. Hypothyroidism prevalances in patients with long duration of amiodarone therapy, but high dose therapy may induce thyrotoxicosis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Arrhythmias, Cardiac
/
Thyroid Diseases
/
Thyroid Function Tests
/
Thyroid Gland
/
Body Height
/
Body Weight
/
Thyrotoxicosis
/
Body Mass Index
/
Medical Records
/
Incidence
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2003
Document type:
Article