Eradication Rates of 10-day Sequential Therapy for Helicobacter pylori: Results of an 8-year Prospective Study Conducted at a Tertiary Korean Hospital / 대한소화기학회지
The Korean Journal of Gastroenterology
; : 99-104, 2019.
Article
in Ko
| WPRIM
| ID: wpr-742135
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: The Helicobacter pylori (H. pylori) eradication rate of standard triple therapy is unsatisfactory in Korea, and sequential therapy (SQT) has been suggested to be a practical first-line alternative regimen. The aim of this prospective study was to document changes in annual eradication rates of SQT. METHODS: A total of 983 H. pylori-positive subjects were enrolled from 2010 to 2018 and their data were subjected to intention-to-treat (ITT) and per-protocol (PP) analysis. All subjects received 10-day sequential therapy consisting of 40 mg esomeprazole and 1 g amoxicillin b.i.d for 5 days followed by 40 mg esomeprazole b.i.d, 500 mg clarithromycin b.i.d and 500 mg metronidazole t.i.d for 5 days. The 13C-urea breath test, rapid urease test (CLO test®), and histology were used to confirm eradication. Compliance and side effects were also investigated. RESULTS: ITT and PP eradication rates of SQT were 69.9% (687 of 983) and 87.1% (657 of 754), respectively. The annual eradication rate of ITT remained consistent over the 8-year study period (p for trend=0.167), whereas PP analysis showed the eradication rate increased (p for trend=0.042). The overall adverse event rate for SQT was 41.7% (410 subjects). CONCLUSIONS: Despite high antibiotic resistance rates in Korea, the eradication rate of SQT did not decrease over the 8-year study period.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Urease
/
Breath Tests
/
Drug Resistance, Microbial
/
Prospective Studies
/
Helicobacter pylori
/
Helicobacter
/
Clarithromycin
/
Compliance
/
Intention to Treat Analysis
/
Esomeprazole
Type of study:
Guideline
/
Observational_studies
Country/Region as subject:
Asia
Language:
Ko
Journal:
The Korean Journal of Gastroenterology
Year:
2019
Document type:
Article