Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up
The Korean Journal of Parasitology
; : 39-41, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-742307
Responsible library:
WPRO
ABSTRACT
In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P < 0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Chagas Disease
/
Neglected Diseases
/
Trypanosomiasis
Database:
WPRIM (Western Pacific)
Main subject:
Trypanosoma
/
Trypanosoma cruzi
/
Immunoglobulin G
/
Immunoglobulins
/
Enzyme-Linked Immunosorbent Assay
/
Follow-Up Studies
/
Chagas Disease
/
Fluorescent Antibody Technique, Indirect
/
Nifurtimox
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2019
Document type:
Article