Understanding the pharmacokinetics of prodrug and metabolite
Translational and Clinical Pharmacology
; : 1-5, 2018.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-742398
Responsible library:
WPRO
ABSTRACT
This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism. In this model, the prodrug is metabolized and produces the parent drug, which is subsequently eliminated. The mathematical expressions for pharmacokinetic parameters were derived step by step. In addition, we visualized these expressions to help understand the relationship between pharmacokinetic parameters easily. For the elimination rate-limited and formation rate-limited metabolism, we analyzed the plasma drug concentration versus time curve of a prodrug administered intravenously.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Parents
/
Plasma
/
Pharmacokinetics
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Translational and Clinical Pharmacology
Year:
2018
Document type:
Article