Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression
Yonsei Medical Journal
; : 319-325, 2019.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-742552
Responsible library:
WPRO
ABSTRACT
Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and its high rates of relapse and metastasis are associated with a poor prognosis. Despite extensive research, the underlying regulatory mechanisms of CRC remain unclear. Long noncoding RNAs (lncRNAs) are a major type of noncoding RNAs that have received increasing attention in the past few years, and studies have shown that they play a role in many biological processes in CRC. Here, we summarize recent studies on lncRNAs associated with CRC and the signaling pathways and mechanisms underlying this association. We show that dysregulated lncRNAs may be new prognostic and diagnostic biomarkers or therapeutic targets for clinical application. This review contributes not only to our understanding of CRC, but also suggests novel signaling pathways associated with lncRNAs that can be targeted to block or eradicate CRC.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Colon and Rectum Cancers
Database:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Biological Phenomena
/
Biomarkers
/
Colorectal Neoplasms
/
Colon
/
Colonic Neoplasms
/
RNA, Untranslated
/
RNA, Long Noncoding
/
Neoplasm Metastasis
Type of study:
Prognostic study
Language:
English
Journal:
Yonsei Medical Journal
Year:
2019
Document type:
Article