Clinical Significance of Serum CA-125 in Korean Females with Ascites
Yonsei Medical Journal
; : 1241-1247, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-74277
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Mycobacterium tuberculosis is endemic in Korea. Because tuberculous peritonitis is characterized by ascites, abdominal pain, abdominal mass and elevation of serum CA-125, it can be confused with ovarian malignancies. The aim of this study was to evaluate the significance of serum CA-125 level in the differential diagnosis of tuberculous peritonitis and ovarian malignancy in a Mycobacterium tuberculosis-endemic area. MATERIALS ANDMETHODS:
The medical records of patients diagnosed with tuberculous peritonitis (n=48) or epithelial ovarian malignancy (n=370) at Samsung Medical Center from January 2000 to October 2009 were retrospectively reviewed.RESULTS:
Median serum CA-125 level in the epithelial ovarian cancer group was significantly higher than that in the tuberculous peritonitis group (p< or =0.01). Only one patient (2.1%) in the tuberculous peritonitis group had a serum CA-125 level over 2000 U/mL. However, 109 patients (29.5%) in the epithelial ovarian cancer group had a serum CA-125 level over 2000 U/mL. At the CA-125 ranges of 400 to 599 and 600 to 799, the proportions of those with tuberculous peritonitis were 24% and 21.9%, respectively. At a serum CA-125 level over 1000 U/mL, however, the proportion of tuberculous peritonitis was much lower (2.1%).CONCLUSION:
Tuberculous peritonitis should be considered in the evaluation of female patients with ascites and high serum CA-125.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Tuberculosis
Database:
WPRIM (Western Pacific)
Main subject:
Ovarian Neoplasms
/
Ascites
/
Peritonitis, Tuberculous
/
Multivariate Analysis
/
Retrospective Studies
/
CA-125 Antigen
/
Diagnosis, Differential
/
Republic of Korea
Type of study:
Diagnostic study
/
Observational study
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Document type:
Article