Role of Prostate Volume in the Early Detection of Prostate Cancer in a Cohort with Slowly Increasing Prostate Specific Antigen
Yonsei Medical Journal
; : 1202-1206, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-74283
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To investigate the relationship between prostate volume and the increased risk for being diagnosed with prostate cancer (PCa) in men with slowly increasing prostate specific antigen (PSA). MATERIALS ANDMETHODS:
A cohort of 1035 men who visited our hospital's health promotion center and were checked for serum PSA levels more than two times between January 2001 and November 2011 were included. Among them, 116 patients had a change in PSA levels from less than 4 ng/mL to more than 4 ng/mL and underwent transrectal ultrasound guided prostate biopsy. Median age was 55.9 years and 26 (22.4%) had PCa. We compared the initial PSA level, the last PSA level, age, prostate volume, PSA density (PSAD), PSA velocity, and follow-up period between men with and without PCa. The mean follow-up period was 83.7 months.RESULTS:
Significant predictive factors for the detection of prostate cancer identified by univariate analysis were prostate volume, follow-up period and PSAD. In the multivariate analysis, prostate volume (p<0.001, odds ratio 0.890) was the most significant factor for the detection of prostate cancer. In the receiver operator characteristic curve of prostate volume, area under curve was 0.724. At the cut-off value of 28.8 mL for prostate volume, the sensitivity and specificity were 61.1% and 73.1% respectively.CONCLUSION:
In men with PSA values more than 4 ng/mL during the follow-up period, a small prostate volume was the most important factor in early detection of prostate cancer.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Prostate
/
Prostatic Neoplasms
/
Biopsy
/
Odds Ratio
/
Multivariate Analysis
/
Cohort Studies
/
Sensitivity and Specificity
/
Prostate-Specific Antigen
/
Early Diagnosis
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Document type:
Article