Notch signaling pathway and bronchopulmonary dysplasia / 国际儿科学杂志

ABSTRACT

Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by various physical and chemical factors,which causes immature lung injury and abnormal repair after injury.In recent years,BPD has become one of the most difficult problems in neonatal intensive care unit.Notch signaling pathway is a conservative pathway that plays a regulatory role in embryonic development.Notch signaling pathways have a wide range of biological effects.By mediating cell-to-cell interactions,Notch signals can finely regulate the growth,development and apoptosis of cells.This article reviews the relationship between Notch signaling pathway and BPD in lung development,hyperoxia-induced lung injury and lung regeneration.