Autophagy in tumorigenesis and cancer therapy / 国际肿瘤学杂志

ABSTRACT

Autophagy is a crucial physiological process for cellular self-renewing and homeostasis,which plays a dual role in both tumorigenesis and anti-tumor treatment.It plays an antineoplastic role by maintaining genomic stability,as well as a protective role in tumorgenesis and progression.Autophagy improves the effectiveness of anti-tumor therapy,meanwhile,it involves in resistance of tumor cells to chemotherapy and irradiation.Using relevant autophagy regulators in different backgrounds is expected to become a new strategy for improving sensitivity of tumor cells to anti-tumor treatment.