Neurotrophins up-express in peripheral blood of allergic rhinitis patients and related to Th2 hypothesis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 1024-1027, 2014.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-746461
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To detect the expression of NGF, BDNF, NT-3 mRNA in the peripheral blood of patients with allergic rhinitis (AR). And to analyze the correlation between NGF, BDNF, NT-3 mRNA expression and the epidsode of rhinitis through Th-2 Hypothesis.@*METHOD@#This study was a group controlled trial. The expression of NGF, BDNF and NT-3 mRNA were tested by real-time quantitative RT-PCR and the concentrations of IL-4, IL-6, IL-10 and INF-alpha were tested by ELISA.@*RESULT@#The expression of NGF, BDNF and NT-3 mRNA in AR patients were 2.44, 4.46 and 1.78 times the amount of those in the healthy adults, respectively. The increased expression of NT-3 correlated positively with the scores of visual analog scale of AR. The concentrations of IL-4, IL-6 and IL-10, which were 2198 +/- 472 pg/mL, 9407 +/- 703 pg/mL and 3917 +/- 323 pg/mL respectively, were higher than those in the healthy adults. The concentration of INF-alpha was 2198 +/- 472 pg/mL and less than the healthy adults. The increased expressions of NGF, NT-3 were positively related to the increase of IL-4, IL-6 and IL-10.@*CONCLUSION@#The expressions of NGF, BDNF and NT-3 mRNA in AR patients are higher than those in the healthy adults. NGF, BDNF and NT-3 may contribute to the pathogenesis of AR. Moreover, NGF and NT-3 may induce the episode of rhinitis through Th-2 Hypothesis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Blood
/
RNA, Messenger
/
Case-Control Studies
/
Interleukin-4
/
Interleukin-6
/
Interleukin-10
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Brain-Derived Neurotrophic Factor
/
Nerve Growth Factor
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Neurotrophin 3
/
Allergy and Immunology
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
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Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2014
Document type:
Article