Research on apoptosis changes of tensor veli palatini in patients with obstructive sleep apnea-hypopnea syndrome / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 108-111, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-746643
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To explore apoptosis changes of dilator muscles in the upper airway by detecting the expression of Bax, Bcl-2 in tensor veli palatini in patients with OSAHS.@*METHOD@#The expression of Bax and Bcl-2 were detected in tensor veli palatini in 30 cases with OSAHS and 10 cases chronic tonsillitis without OSAHS by immunohistochemistry and image analytical system, and the results were analyzed.@*RESULT@#(1) The expression levels of Bax in the OSAHS group increased significantly compared to control group (P < 0.05), but there were no significant differences of Bcl-2 expression between two groups, the ratio of Bax/Bcl-2 increased significantly (P < 0.05). (2) There were positive correlations between AHI and the expression levels of Bax (r = 0.697, P < 0.01) respectively in the test group.@*CONCLUSION@#The results indicate that apoptosis occurred in tensor veli palatini in patients with OS AHS, and the more severity of OSAHS, the more apoptosis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Palatal Muscles
/
Pathology
/
Case-Control Studies
/
Airway Resistance
/
Proto-Oncogene Proteins c-bcl-2
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Sleep Apnea, Obstructive
/
Bcl-2-Associated X Protein
/
Metabolism
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2010
Document type:
Article