Expressions and correlations of Survivin, Ki67 and p53 in laryngeal squmous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 1545-1548, 2015.
Article
in Zh
| WPRIM
| ID: wpr-747852
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression of Survivin, p53 and Ki67 in laryngeal carcinoma and the relation with clinical data.@*METHOD@#Immunohistochemical staining (SP) was used to detect expression of Survivin, p53 and Ki67 of 64 cases with laryngeal carcinoma, 26 cases with precancerosis, 34 cases with vocal polyps.@*RESULT@#The positive expression rates of Survivin, p53 and Ki67 were 59.4%, 68.8%, 65.6% respectively in laryngeal carcinoma, which were significantly higher than those in precancerosis and vocal polyps (P 0.05). The expression of Survivin, Ki-67 and p53 was positively correlated (r = 0.607, 0.541, 0.648, P < 0.01) in laryngeal carcinoma.@*CONCLUSION@#Survivin, p53 and Ki-67 may play an important role in the carcinogenesis and progress of laryngeal carcinoma. They may play synergetic roles in the process of carcinogenesis of laryngeal carcinoma.
Full text:
1
Database:
WPRIM
Main subject:
Polyps
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
Tumor Suppressor Protein p53
/
Ki-67 Antigen
/
Inhibitor of Apoptosis Proteins
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Survivin
/
Larynx
/
Lymphatic Metastasis
Limits:
Humans
Language:
Zh
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2015
Document type:
Article