The dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa in the allergic rhinitis rat models / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 655-658, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-747933
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the dynamic expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rat models of allergic rhinitis, at different stages of the process during pathogenesis.@*METHOD@#One hundred and eighty Sprague-Dawley (SD) rats were randomly divided into three groups, the normal Group A used for contrast and experimental groups Group B and C, each group were 60 rats. Then, observed the expression of the TGF-beta1 and FGF-2 in the nasal mucosa at different stages of the process by immunohistochemical staining.@*RESULT@#The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of the normal Group A was negative, while the Group B and Group C were varying degrees of positive both, and Group B, the level of the TGF-beta1 and FGF-2 were both decline after allergen avoidance, but still more not ability than the expression of the Group B (P < 0.05).@*CONCLUSION@#The expression of the TGF-beta1 and FGF-2 in the nasal mucosa of rats models were varying degrees of positive , and it is decline while the allergen avoidance.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Rhinitis, Allergic, Perennial
/
Fibroblast Growth Factor 2
/
Rats, Sprague-Dawley
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Transforming Growth Factor beta1
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Metabolism
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Nasal Mucosa
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2010
Document type:
Article