Mitochondrial DNA mutations and aminoglycoside antibiotics and hearing loss / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 1936-1940, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-749126
Responsible library:
WPRO
ABSTRACT
Mitochondrial DNA mutations are one of the most important causes of sensorineural hearing loss. A1555G and C1494T mutations of mitochondrial 12S rRNA gene are the molecular basis for aminoglycoside hyper- sensitivity and can lead to aminoglycoside-induced hearing loss. Primary mutations in tRNA such as tRNA(Ser(UCN))7472insC are associated with syndromic hearing loss. While other mutations such as tRNA"(Se(UCN) )G7444A were considered synergy with the primary RNA mutations, modulating the phenotypic manifestation. This review de- scribes a detailed summary of hearing loss associated with mtDNA mutations and/or aminoglycoside antibiotics, and provides the possible molecular mechanisms in deafness expression.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
DNA, Mitochondrial
/
RNA, Ribosomal
/
Genetics
/
Aminoglycosides
/
Hearing Loss, Sensorineural
/
Anti-Bacterial Agents
/
Mutation
Limits:
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2015
Document type:
Article