Significance expression and relationships with endothelin-1, matrix metalloproteinase-9 in the laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 245-251, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-749445
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate the expression of endothelin-1(ET-1) and matrix metalloproteinase-9 (MMP-9) in laryngeal carcinoma and their correlations with clinical features.@*METHOD@#The expression of ET-1 and MMP-9 was detected by immunohistochemical method in 58 specimens of laryngeal carcinoma, 28 specimens of polyps of vocal cord and 19 specimens of normal laryngeal tissues.@*RESULT@#The expressions of ET-1, MMP-9 in laryngeal carcinoma were remarkably higher,compared to polyps of vocal cord and normal laryngeal tissues (P < 0.05). The expression of ET-1, MMP-9 was associated with clinical stage, T stage and lymph node metastasis. Expression levels of ET-land MMP-9 correlated significantly with each other (r(s) = 0.693, P < 0.05).@*CONCLUSION@#The expression of ET-1 and MMP-9 may be the vital indexes in laryngeal carcinoma.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
Endothelin-1
/
Matrix Metalloproteinase 9
/
Metabolism
/
Neoplasm Staging
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2012
Document type:
Article