Pholcodine consumption and immunoglobulin E-sensitization in atopics from Australia, Korea, and Japan
Asia Pacific Allergy
; (4): 86-90, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-749986
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Accumulating data indicates that pholcodine (PHO)-consuming countries have higher sero-prevalences of immunoglobulin E (IgE)-antibodies to PHO and suxamethonium (SUX) and increased frequencies of IgE-mediated anaphylaxis to neuromuscular blocking agents (NMBAs) than nonconsuming. Withdrawing PHO-containing cough syrups resulted in a significant decrease of cases with anaphylaxis in Scandinavia. Nevertheless, the European Medicines Agency in 2011 advised to continue the unrestricted use throughout the European Union.OBJECTIVE:
To extend studies on PHO consumption and prevalence of IgE-sensitization to morphine (MOR), PHO, and SUX to countries representing high (Australia), and low (Korea and Japan), consumers, respectively.METHODS:
IgE-antibodies to SUX, MOR, and PHO in atopic subjects were determined by immunoassay and compared with official figures for PHO consumption and reported anaphylaxis to NMBA.RESULTS:
The prevalences of IgE-antibodies to PHO, MOR, and SUX were 10%, 8.6%, and 4.3%, respectively, in Australia. The corresponding figures for Japan were 0.8%, 0.8%, and 1.5%, and for Korea 1.0% to PHO and 0.5% to MOR and SUX. Of the SUX-positive sera, 100% were positive to PHO or MOR in Australia and 0% in Japan and Korea.CONCLUSION:
The study supports previous findings; exposure to PHO may induce IgE-antibodies to the substituted ammonium ion epitope of NMBAs, thus increasing risk of NMBA-induced anaphylaxis considerably. However, other, still unknown factors occasionally might induce IgE-antibodies to SUX.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Scandinavian and Nordic Countries
/
Australia
/
Succinylcholine
/
Immunoglobulin E
/
Immunoglobulins
/
Immunoassay
/
Prevalence
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Cough
/
European Union
/
Ammonium Compounds
Type of study:
Prevalence study
Country/Region as subject:
Asia
/
Europa
/
Oceania
Language:
English
Journal:
Asia Pacific Allergy
Year:
2014
Document type:
Article