Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
Asia Pacific Allergy
; (4): 253-256, 2014.
Article
in En
| WPRIM
| ID: wpr-749999
Responsible library:
WPRO
ABSTRACT
Lamotrigine is a recent medication which is prescribed for various neuropsychiatric conditions. It is generally well-tolerated, but recent pharmacoepidemiological evidence suggests that lamotrigine is associated with risks of developing severe cutaneous drug reactions like toxic epidermal necrolysis (TEN). However, there still remains the diagnostic challenge regarding how to confirm the drug causality in suspected cases. In most cases so far, lamotrigine causality has not been objectively demonstrated, which was possibly due to high risk of oral challenge tests or the lack of useful in vitro drug assays. Here we report a case of lamotrigine-induced TEN, of which the drug causality was confirmed by in vitro granulysin and cytokine assays.
Key words
Full text:
1
Database:
WPRIM
Main subject:
In Vitro Techniques
/
Killer Cells, Natural
/
Stevens-Johnson Syndrome
/
Cyclosporine
Language:
En
Journal:
Asia Pacific Allergy
Year:
2014
Document type:
Article