Economic value of atopic dermatitis prevention via infant formula use in high-risk Malaysian infants
Asia Pacific Allergy
; (4): 84-97, 2015.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-750022
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
Breastfeeding is best for infants and the World Health Organization recommends exclusive breastfeeding for at least the first 6 months of life. For those who are unable to be breastfed, previous studies demonstrate that feeding high-risk infants with hydrolyzed formulas instead of cow's milk formula (CMF) may decrease the risk of atopic dermatitis (AD).OBJECTIVE:
To estimate the economic impact of feeding high-risk, not exclusively breastfed, urban Malaysian infants with partiallyhydrolyzed whey-based formula (PHF-W) instead of CMF for the first 17 weeks of life as an AD risk reduction strategy.METHODS:
A cohort Markov model simulated the AD incidence and burden from birth to age 6 years in the target population fed with PHF-W vs. CMF. The model integrated published clinical and epidemiologic data, local cost data, and expert opinion. Modeled outcomes included AD-risk reduction, time spent post AD diagnosis, days without AD flare, quality-adjusted life years (QALYs), and costs (direct and indirect). Outcomes were discounted at 3% per year. Costs are expressed in Malaysian Ringgit (MYR; MYR 1,000 = United States dollar [US $]316.50).RESULTS:
Feeding a high-risk infant PHF-W vs. CMF resulted in a 14% point reduction in AD risk (95% confidence interval [CI], 3%-23%), a 0.69-year (95% CI, 0.25-1.10) reduction in time spent post-AD diagnosis, additional 38 (95% CI, 2-94) days without AD flare, and an undiscounted gain of 0.041 (95% CI, 0.007-0.103) QALYs. The discounted AD-related 6-year cost estimates when feeding a high-risk infant with PHF-W were MYR 1,758 (US $556) (95% CI, MYR 917-3,033) and with CMF MYR 2,871 (US $909) (95% CI, MYR 1,697-4,278), resulting in a per-child net saving of MYR 1,113 (US $352) (95% CI, MYR 317-1,884) favoring PHF-W.CONCLUSION:
Using PHF-W instead of CMF in this population is expected to result in AD-related costs savings.
Full text:
Available
Health context:
SDG3 - Target 3.8 Achieve universal access to health
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SDG3 - Health and Well-Being
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SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Delivery Arrangements
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Multisectoral Coordination
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Target 3.8 Achieve universal access to health
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Target 3.1: Reduce maternal mortality
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Target 3.2: Reduce avoidable death in newborns and children under 5
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Target 3.7: Universal access to health services related to reproductive and sexual health
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Skin Diseases
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Noncommunicable Diseases
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Nutrition
Database:
WPRIM (Western Pacific)
Main subject:
United States
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World Health Organization
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Breast Feeding
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Incidence
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Cohort Studies
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Cost-Benefit Analysis
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Quality-Adjusted Life Years
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Risk Reduction Behavior
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Parturition
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Infant Formula
Type of study:
Diagnostic study
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Etiology study
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Health economic evaluation
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Incidence study
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Observational study
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Prognostic study
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Risk factors
Aspects:
Social determinants of health
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Patient-preference
Limits:
Humans
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Infant
Country/Region as subject:
North America
Language:
English
Journal:
Asia Pacific Allergy
Year:
2015
Document type:
Article