The role of transcription factor GATA6 in lung development and diseases / 国际儿科学杂志

ABSTRACT

GATA transcription factors encode a zinc finger DNA binding protein and play an important role in regulating cell proliferation and differentiation.GATA6 is an important member of the GATA transcription factor family,mainly expressed in the tissues and organs derived from endoderm.It is also the most fundamental member of the GATA family located in the airway epithelial cells.It is involved not only in the regulation of normal lung tissue development,but also in the pathogenesis of lung diseases.This review focuses on the role of GATA6 in lung development and some lung diseases.