Effect of ubiquitin-specific protease on radiosensitivity of tumor / 国际肿瘤学杂志

ABSTRACT

Ubiquitin-specific protease is a member of the deubiquitinating enzyme family,which can reverse the ubiquitination of proteins and stabilize proteins. It affects radiosensitivity of tumor by regulating DNA damage,cell cycle,nuclear factor-κB signaling pathway,Nrf2-Keap1 signaling pathway and oncogene c-myc. It is expected to become a new target for tumor radiotherapy sensitization.