Research progress of the nano drug-loading systems targeting tumor stem cells / 实用肿瘤学杂志

ABSTRACT

Cancer is one of the major diseases that seriously endanger human health. Recurrence and metastasis may still oc-cur after traditional treatment. The basic reason is the presence of cancer stem cells(CSCs)in tumor tissues. CSCs have a high degree of proliferative ability,self-renewal,multi-directional differentiation,highly tumorigenicity and multi-drug resistance,which control the occurrence and development of tumors,chemotherapy tolerance,recurrence and metastasis. Therefore,clearing CSCs is one of effec-tive ways to improve the curative rate of cancer. Nano-carriers have many advantages such as small size,large specific surface area, good biocompatibility and degradation in vivo. They are often used for targeted delivery and sustained release of drugs,which overcome the toxic side effects of traditional chemotherapeutic drugs,avoid surgical damage and kill CSCs. This paper will review the characteris-tics of CSCs and nano drug-loading systems as well as their research progress of nano drug-loading systems in CSCs in recent years.